We have set up a tissue-based screening tool by using micro-dissected human sebaceous glands, aimed to test potential modulators of sebogenesis.

In contrast to the use of sebocyte cell lines, this model allows to reproduce the metabolism and organization of the whole organ, thus being representative of the in-vivo situation.

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Skin Tests - Sebaceous Gland - Collagen I
Sebaceous Gland - Collagen l

Sebum modulation

The modulation of sebum is measured by the quantification of total lipids using infrared (IR) spectroscopy analysis.

Depending on the potential mechanism of action of the product, additional specific pathways can be investigated, such as FADS2, SCD1, PPAR alpha, PPAR gamma, or TRPV1.